生物反应器
生物反应器有各种尺寸和类型（不锈钢、一次性或混合型），可支持贴壁细胞和悬浮细胞培养。贴壁细胞系可在批次或补料批次模式下培养，也可采用培养基置换法；而悬浮细胞则可在批次、补料批次和灌流模式下培养。 无论细胞类型或操作模式如何，生物反应器都必须能够确保细胞生长稳定、细胞存活率高以及蛋白质产量稳定。在工艺开发过程中，会使用缩小规模、工作体积较小的小型微生物反应器来预测大型反应器的性能，从而为临床和商业生产或技术转移的放大过程提供便利。
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