细胞培养基滤器
细胞培养基过滤器的灭菌
Millipore Express® SHC（无菌、高容量）滤器为细胞培养基的过滤提供了极高的过滤容量。集成的0.5 µm聚醚砜（PES）膜预滤器可保护0.2 µm PES灭菌膜，从而最大化滤器容量并提高过滤的可靠性。
- Millipore Express® SHC 滤器具有高通量特性，易于润湿和进行完整性测试，且具有广泛的化学兼容性。
- 大面积胶囊和滤芯规格在不增加占地面积的前提下，最大限度地提高了过滤效率。
用于细胞培养基的支原体去除滤器
Millipore Express® SHR 滤器（无菌、高截留）可实现≥ 7.0 log 的支原体去除率，并具备无菌级性能，适用于需要额外安全保障的上游工艺。0.1 µm 支原体截留 PES 膜兼具高通量与卓越的微生物截留能力。
针对更易堵塞的细胞培养基，我们的Millipore Express® SHRP滤器内置0.5 µm PES预滤器，可保护0.1 µm支原体截留膜，从而提高滤器容量并增强工艺的稳健性。
从实验室到生产规模的各种规格
我们的细胞培养基滤器提供：
- OptiScale® 规格，用于高效筛选和规模化生产；以及在制造过程中经过 100% 完整性测试的滤芯和胶囊规格。
- 大面积胶囊和滤芯规格，在不增加占地面积的前提下最大限度提高过滤效率。
- 可高压灭菌、预灭菌或适配伽马射线灭菌的规格，可集成至 Mobius® 一次性组件中。
胶囊和滤芯过滤器的近似过滤面积。有关各产品线的完整信息及精确过滤面积，请参阅产品规格。阅读我们的技术文章，了解不同过滤器规格的更多信息。
产品
Products
质量标准与文件
所有 Millipore Express® 滤器均按照经认可注册机构批准的、符合 ISO 9001 质量管理体系标准的质量管理体系进行设计、开发和制造，并附有质量证书。
所有 Millipore Express® SHC、Millipore Express® SHR 和 Millipore Express® SHRP 滤器均由 Emprove® 计划提供支持，该计划提供三种类型的技术文件，以支持开发和生产运营的不同阶段，例如资格确认、风险评估和工艺优化。这些技术文件以易于获取的格式整合了全面的产品特定测试数据、质量声明和法规信息，助您信心十足地推进工作。
相关资源
- Article: Millipore Express® Express Sterilizing-Grade Membrane Filters Selection Guide
Discover various Millipore Express® sterilizing-grade membrane filters for liquid filtration in aseptic drug production.
- Article: Optimizing Upstream Processing: Media Filtration and Cell Culture Performance
This technical article provides guidance on selecting and sizing filters for cell culture media filtration.
- Application Note: Cell Culture Media Filtration. Selection and Sizing Filters for CHO Cell Culture Processes
Explore throughput performance of Millipore Express® aseptic filters for cell culture media filtration and their impact on filter sizing.
- Application Note: Cell Culture Media Filtration. Evaluating Performance of CHO Cell Cultures
Learn how to check if your media filter impacts performance. Studies confirmed PES and PVDF membrane filters did not affect cell growth and viability.
- Technical Note: Performance of High-Area Millipore Express® Cartridge Filters
High area filters can improve filtration productivity for mid- to high- plugging streams. Read how our model can help predict the benefits for different streams.
- Technical Note: Mycoplasma clearance by Millipore Express® SHR filters at pilot and production scales
Retention studies demonstrate that both pilot and production-scale filters consistently provided the expected level of mycoplasma retention over extended filtration times, affirming their performance under continuous flow processing conditions.
- Application Note: Cell Culture Media Mixing and Microfiltration: Reducing Risk with Single-use Technology
This application note explains considerations for the preparation of cell culture media and focuses on the benefits of mixing and filtration using single use technologies.
- Millipore Express® Family Guide
Read this guide to review key differentiators and product specifications of Millipore Express® membrane filters.
- Technical Note: Integrity Test Troubleshooting - Beyond Rewet and Retest
Filter integrity testing doesn’t always go smoothly. Learn how to avoid costly mistakes and troubleshoot integrity test challenges.
- Brochure: Vmax™ Constant Pressure Test for sizing Aseptic Filters
This protocol describes how to use results from small scale studies to predict filtration area requirements.
- Article: Prefilters and Sterilizing-grade Filter Formats: Selection Guide
Aseptic filters are offered in disposable capsules and cartridge formats. This guide will help you find the right format for your bioburden control.
相关网络研讨会
为生物制造选择无菌过滤器需根据具体的工艺需求而定。了解如何为您的工艺选择最合适的过滤器。
变更管理通常被认为是一项复杂的工作。了解如何采用基于风险的方法来加快获批后产品的变更流程。
本次网络研讨会将阐述生物负荷失控的影响、生物负荷的来源以及降低风险的策略。降低风险有助于减少故障和调查。
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